A Two-Level, Intramutant Spectrum Haplotype Profile of Hepatitis C Virus Revealed by Self-Organized Maps
ABSTRACT RNA viruses replicate as complex mutant spectra termed viral quasispecies.The frequency of each individual genome in a mutant spectrum depends on its rate of generation and its relative fitness in the replicating population ensemble.The advent of deep sequencing methodologies allows for the first-time quantification of haplotype abundances